Hydroxyurea Pregnancy and Breastfeeding Warnings

Hydroxyurea is also known as: Droxia, Hydrea, Mylocel

Hydroxyurea Pregnancy Warnings

A case has been reported in which a woman who previously had two stillbirths (not receiving hydroxyurea), gave birth to a healthy 6 lb boy after being treated with hydroxyurea for the first six weeks of her pregnancy.

Hydroxyurea has been assigned to pregnancy category D by the FDA. Animal studies have revealed that the drug crosses the placenta. Its use has associated with embryotoxicity, fetal malformations, growth retardation, and impaired learning ability. There are no controlled data in human pregnancy. If hydroxyurea is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.

Hydroxyurea Breastfeeding Warnings

Hydroxyurea is excreted into human milk. Because of the potential for serious adverse reactions with hydroxyurea, a decision should be made either to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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