Hydroxyurea use while Breastfeeding
Drugs containing Hydroxyurea: Hydrea, Droxia, Mylocel
Hydroxyurea Levels and Effects while Breastfeeding
Summary of Use during Lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.
Drug Levels
Maternal Levels. A mother was taking 500 mg of hydroxyurea orally three times a day. Milk samples taken 2 hours after the last dose of each day on 3 days averaged 6.1 mg/L (range 3.8 to 8.4 mg/L). Using these data, the infant in this case would have received less than 4% of maternal weight-adjusted dosage.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Dependent on the condition being treated.
References
1. Sylvester RK, Lobell M, Teresi ME et al. Excretion of hydroxyurea into milk. Cancer. 1987;60:2177-8. PMID: 3481556
Hydroxyurea Identification
Substance Name
CAS Registry Number
127-07-1
Drug Class
- Antineoplastic Agents
Administrative Information
LactMed Record Number
140
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-12-07
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Hydroxyurea use during Pregnancy
- Hydroxyurea Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
