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Guaifenesin / hydrocodone Pregnancy and Breastfeeding Warnings

Guaifenesin / hydrocodone is also known as: A-Cof DH, Co-Tussin, CodiCLEAR DH, Condasin, EndaCof-Tab, Execlear, Flowtuss, Hycotuss Expectorant, Hydrocod-GF, Kwelcof, Maxi-Tuss HCG, Narcof, Obredon, Pneumotussin 2.5, Pneumotussin HC, Propatuss Expectorant, Relasin-HCX, Tusso-HC, Vi-Q-Tuss, Vicoclear, Vicodin Tuss, Vicotuss, Vitussin Expectorant, Vortex, Ztuss ZT

Guaifenesin / hydrocodone Pregnancy Warnings

Guaifenesin-hydrocodone has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted on this combination product. There are no controlled data on this combination product in human pregnancy. Guaifenesin-hydrocodone is only recommended for use during pregnancy when benefit outweighs risk.

Detailed information about the use of hydrocodone in pregnancy is not available. Animal studies have reported the occurrence of teratogenic effects at doses 700 times the human dose. Withdrawal symptoms and respiratory depression have been reported in neonates whose mothers took other narcotic analgesics during pregnancy.

See references

Guaifenesin / hydrocodone Breastfeeding Warnings

There are no data on the excretion of guaifenesin and hydrocodone into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue guaifenesin and hydrocodone, taking into account the importance of guaifenesin and hydrocodone to the mother.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Vicodin Tuss (guaifenesin-hydrocodone)" Knoll Pharmaceutical Company, Mount Olive, NJ.
  3. Rementeria JL, Nunag NN "Narcotic withdrawal in pregnancy: stillbirth incidence with a case report." Am J Obstet Gynecol 116 (1973): 1152-6
  4. Zelson C, Lee SJ, Casalino M "Neonatal narcotic addiction: comparative effects of maternal intake of heroin and methadone." N Engl J Med 289 (1973): 1216-20

References for breastfeeding information

  1. "Product Information. Vicodin Tuss (guaifenesin-hydrocodone)" Knoll Pharmaceutical Company, Mount Olive, NJ.

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