Frovatriptan Pregnancy and Breastfeeding Warnings
Frovatriptan is also known as: Frova
Frovatriptan Pregnancy Warnings
Frovatriptan has been assigned to pregnancy category C by the FDA. When pregnant rats were administered frovatriptan during the period of oganogenesis at oral doses equivalent to 130 to 1,300 times the maximum recommended human dose (based on a mg/m2 dosage regimen), there was a dose related increased incidence of litters and total numbers of fetuses with dilated ureters, unilateral and bilateral pelvic cavitation, hydronephrosis, and hydroureters. When pregnant rabbits were dosed throughout organogenesis at doses up to 210 times the maximum recommended human dose (based on a mg/m2 dosage regimen), no effects on fetal development were observed. There are no controlled data in human pregnancy. Frovatriptan is only recommended for use during pregnancy when benefit outweighs risk.
Frovatriptan Breastfeeding Warnings
Frovatriptan and/or its metabolites are excreted in the milk of lactating rats with the maximum concentration being four-fold higher than that seen in blood.
There are no data on the excretion of frovatriptan into human milk. The manufacturer recommends exercising caution when administering frovatriptan to nursing mothers.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.