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Frovatriptan Pregnancy and Breastfeeding Warnings

Frovatriptan is also known as: Frova

Frovatriptan Pregnancy Warnings

Frovatriptan has been assigned to pregnancy category C by the FDA. When pregnant rats were administered frovatriptan during the period of oganogenesis at oral doses equivalent to 130 to 1,300 times the maximum recommended human dose (based on a mg/m2 dosage regimen), there was a dose related increased incidence of litters and total numbers of fetuses with dilated ureters, unilateral and bilateral pelvic cavitation, hydronephrosis, and hydroureters. When pregnant rabbits were dosed throughout organogenesis at doses up to 210 times the maximum recommended human dose (based on a mg/m2 dosage regimen), no effects on fetal development were observed. There are no controlled data in human pregnancy. Frovatriptan is only recommended for use during pregnancy when benefit outweighs risk.

Frovatriptan Breastfeeding Warnings

Frovatriptan and/or its metabolites are excreted in the milk of lactating rats with the maximum concentration being four-fold higher than that seen in blood.

There are no data on the excretion of frovatriptan into human milk. The manufacturer recommends exercising caution when administering frovatriptan to nursing mothers.

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