Fluvastatin Pregnancy and Breastfeeding Warnings

Fluvastatin is also known as: Lescol, Lescol XL

Fluvastatin Pregnancy Warnings

Fluvastatin has been assigned to pregnancy category X by the FDA. While animal studies with fluvastatin failed to reveal evidence of teratogenicity, animal studies with other HMG-CoA reductase inhibitors revealed an increase in the incidence of skeletal malformations. There are no controlled data in human pregnancy. However, HMG-CoA reductase inhibitors are known to inhibit biosynthetic processes necessary in fetal development. Fluvastatin use is considered contraindicated during pregnancy.

Fluvastatin Breastfeeding Warnings

Fluvastatin is excreted into human milk. According to the manufacturer, the breast milk to plasma ratio of fluvastatin based on preclinical data is 2:1. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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