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Generic Name: fluvastatin (FLOO va sta tin)
Brand Names: Lescol, Lescol XL

What is Lescol?

Lescol (fluvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Fluvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Lescol is used to lower cholesterol and triglycerides (types of fat) in the blood and to slow the build-up of plaque (fatty deposits) in your blood vessels.

Lescol is also used to lower the risk of heart complications in certain people with coronary artery disease. Fluvastatin is used in adults and children who are at least 10 years old.

Important information

Lescol can harm an unborn baby or cause birth defects. Do not use fluvastatin if you are pregnant.

You should not take Lescol if you have liver disease, or if you are breast-feeding a baby.

Before taking Lescol, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, or if you drink more than 2 alcoholic beverages daily.

Some medicines can cause unwanted or dangerous effects when used with fluvastatin. Tell your doctor about all other medicines you use.

In rare cases, fluvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Avoid eating foods that are high in fat or cholesterol. Lescol will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Lescol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Before taking this medicine

You should not take Lescol if you are allergic to fluvastatin, or if:

  • you have active liver disease; or

  • you are pregnant or breast-feeding.

To make sure Lescol is safe for you, tell your doctor if you have:

  • a history of liver disease;

  • muscle pain or weakness;

  • kidney disease;

  • diabetes;

  • a thyroid disorder; or

  • if you drink more than 2 alcoholic beverages daily.

Lescol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

The following drugs can increase your risk of serious muscle problems if you take them together with Lescol:

  • colchicine;

  • erythromycin;

  • fluconazole;

  • glyburide;

  • phenytoin;

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • cyclosporine or other drugs that weaken your immune system;

  • gemfibrozil, fenofibric acid, fenofibrate; or

  • medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).

Lescol can harm an unborn baby or cause birth defects. Do not take Lescol if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Use effective birth control to prevent pregnancy while you are taking this medicine.

Fluvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Lescol.

This medicine is not approved for use by anyone younger than 10 years old.

How should I take Lescol?

Take Lescol exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

Lescol is usually taken once or twice daily, with or without food. Take the medicine at the same time each day.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Tell your doctor if you have trouble swallowing the pill.

While using this medicine, you may need frequent blood tests.

It may take up to 4 weeks before your cholesterol levels improve. Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms.

Lescol is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Lescol dosing information

Usual Adult Dose for Hyperlipidemia:

Initial dose: 20 to 40 mg orally once a day at bedtime.
Maintenance dose: 20 to 80 mg/day.

Usual Pediatric Dose for Hyperlipidemia:

9 to 16 years:
Initial dose: 20 mg orally once a day at bedtime.
Maintenance dose: 20 to 80 mg/day.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lescol?

Avoid eating foods that are high in fat or cholesterol. Lescol will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Lescol side effects

Get emergency medical help if you have signs of an allergic reaction to Lescol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, fluvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Also call your doctor at once if you have:

  • signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or

  • liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Lescol side effects may include:

  • muscle pain;

  • headache; or

  • stomach pain, nausea, or indigestion.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Lescol?

Many other drugs can increase your risk of muscle problems if you take them with Lescol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Lescol. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Lescol.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lescol only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 12.01. Revision Date: 2016-03-22, 11:04:04 AM.

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