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Flurbiprofen Pregnancy and Breastfeeding Warnings

Flurbiprofen is also known as: Ansaid

Flurbiprofen Pregnancy Warnings

Flurbiprofen has been assigned to pregnancy category C by the FDA. Reproductive studies conducted in rats and rabbits have not demonstrated evidence of developmental abnormalities. However, animal reproduction studies are not always predictive of human response. Because of the known effects of nonsteroidal anti-inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus), use during late pregnancy should be avoided. There are no adequate and well-controlled studies in pregnant women. Flurbiprofen should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

See references

Flurbiprofen Breastfeeding Warnings

Flurbiprofen is excreted in small amounts in human milk. Concentrations of flurbiprofen in breast milk and plasma of nursing mothers suggest that a nursing infant could receive approximately 0.10 mg flurbiprofen per day in the established milk of a woman taking 200 mg/day. The manufacturer states that because of possible adverse effects of prostaglandin-inhibiting drugs on neonates, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. However, Briggs et. al. has assigned flurbiprofen to risk factor C and states that in studies conducted on lactating women who were not breastfeeding, small amounts of flurbiprofen recovered from transitional and mature breast milk seem to indicate that the risk posed by flurbiprofen to a nursing infant is slight, if it exists at all. They classified flurbiprofen as one of several low-risk alternatives, because of its short adult serum half-life and toxicity profile compared with other similar agents, if an NSAID was required while nursing.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.

References for breastfeeding information

  1. Smith IJ, Hinson JL, Johnson VA, Brown RD, Cook SM, Whitt RT, Wilson JT "Flurbiprofen in post-partum women: plasma and breast milk disposition." J Clin Pharmacol 29 (1989): 174-84
  2. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  3. Briggs GG, Freeman RK, Yaffe SJ. "Drugs in Pregnancy and Lactation. 8th ed." Philadelphia, PA: Lippincott Williams & Wilkins (2008):
  4. Cox SR, Forbes KK "Excretion of flurbiprofen into breast milk." Pharmacotherapy 7 (1987): 211-5

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