Flurbiprofen Pregnancy and Breast Feeding Warnings

Flurbiprofen is also known as: Ansaid

Overview

Flurbiprofen may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flurbiprofen while you are pregnant. Flurbiprofen is found in breast milk. Do not breast-feed while taking Flurbiprofen .

Flurbiprofen Pregnancy Warnings

Flurbiprofen has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Use late in pregnancy may result in premature closure of the ductus arteriosus and prolong labor and delivery. Flurbiprofen is only recommended for use during pregnancy when benefit outweighs risk. Flurbiprofen should be avoided near term.

Flurbiprofen Lactation Warnings

Flurbiprofen is excreted into human milk in small amounts. While the manufacturer recommends avoidance of flurbiprofen during lactation, other authors have concluded that flurbiprofen is safe during lactation.

Peak flurbiprofen concentrations in milk averaged 0.09 mcg/mL in ten women at least one month postpartum following oral administration of flurbiprofen 100 mg. The mean milk to plasma ratio was 0.02. The maximum recovery of the dose in breast milk averaged 0.07%. A more recent study found similar results in 12 women, three to five days postpartum, who received flurbiprofen 50 mg four times a day for nine doses. Milk concentrations were below the level of detection (<0.05 mcg/mL) in 10 of 12 women. In the other two women, milk concentrations ranged from 0.06 to 0.07 mcg/mL. The authors concluded that flurbiprofen is safe during lactation in the early postpartum period.

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