Advanced Breast Cancer: Learn about treatment options.

Etoposide Pregnancy and Breastfeeding Warnings

Etoposide is also known as: Etopophos, Toposar, VePesid

Etoposide Pregnancy Warnings

Etoposide is teratogenic and embryocidal in rats and mice at doses of 1% to 3% of the recommended clinical dose based on body surface area. In a teratogenicity study in rats, etoposide was administered intravenously at doses of 0.13, 0.4, 1.2, and 3.6 mg/kg/day on days 6 to 15 of gestation. Dose-related maternal toxicity, embryotoxicity and teratogenicity at dose levels of 0.4 mg/kg/day and higher were reported. Embryonic resorptions were 90% and 100% at the 2 highest dosages. At 0.4 and 1.2 mg/kg, fetal weights were decreased and fetal abnormalities including decreased weight, major skeletal abnormalities, exencephaly, encephalocele and anophthalmia occurred. Even at the lowest dose tested, 0.13 mg/kg, a significant increase in retarded ossification was observed. Etoposide administered as a single intraperitoneal injection in mice at dosages of 1, 1.5, and 2 mg/kg on days 6, 7, or 8 of gestation caused dose related embryotoxicity, cranial abnormalities and major skeletal malformations.

Etoposide has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of teratogenicity in mice and rats. There are no controlled data in human pregnancy. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant during therapy. Etoposide should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Etoposide Breastfeeding Warnings

There are no data on the excretion of etoposide into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from etoposide phosphate, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web3)