Etoposide use while Breastfeeding

Drugs containing Etoposide: VePesid, Toposar, Etopophos

Etoposide Levels and Effects while Breastfeeding

Summary of Use during Lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It appears possible to breastfeed safely during intermittent therapy with etoposide after an appropriate period of breastfeeding abstinence. A period of at least 24 hours is required after a dose of 80 mg/sq m or less. Others have suggested an abstinence period of 72 hours after etoposide use.[1]

Drug Levels

Maternal Levels. A woman treated with etoposide, mitoxantrone and cytarabine for promyelocytic leukemia received 5 daily etopside doses of 80 mg/sq m intravenously. Etoposide milk levels reached a peaks of about 600, 580 and 800 mcg/L immediately after the last 3 doses, respectively. Etoposide was undetectable (assay limit not specified) in milk 24 hours after each dose.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

One mother received with 5 daily doses of etopside 80 mg/sq m and cytarabine 170 mg/sq m intravenously as well as 3 daily doses of 6 mg/sq m of mitoxantrone intravenously. She resumed breastfeeding her infant 3 weeks after the third dose of mitoxantrone at a time when mitoxantrone was still detectable in milk. The infant had no apparent abnormalities at 16 months of age.[2]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Pistilli B, Bellettini G, Giovannetti E et al. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013;39:207-11. PMID: 23199900

2. Azuno Y, Kaku K, Fujita N et al. Mitoxantrone and etoposide in breast milk. Am J Hematol. 1995;48:131-2. Letter. PMID: 7847330

Etoposide Identification

Substance Name

Etoposide

CAS Registry Number

33419-42-0

Drug Class

  • Antineoplastic Agents

Administrative Information

LactMed Record Number

108

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-12-06

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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