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Didanosine Pregnancy and Breastfeeding Warnings

Didanosine is also known as: Videx, Videx EC

Didanosine Pregnancy Warnings

An Antiretroviral Pregnancy Registry has been established to monitor maternal-fetal outcomes of didanosine exposures during pregnancy. To register patients, physicians should call 800-258-4263. Fatal lactic acidosis has been reported in pregnant women who received the combination of didanosine and stavudine with other antiretroviral agents. The combination of didanosine and stavudine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs the potential risk.

Didanosine has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal harm to the fetus. There are no controlled data in human pregnancies. Didanosine should only be given during pregnancy when need has been clearly established.

See references

Didanosine Breastfeeding Warnings

There are no data on the excretion of didanosine into human milk. It is excreted into rat milk. The U.S. Public Health Service Centers for Disease Control and Prevention advise HIV-infected women not to breast-feed to avoid postnatal transmission of HIV to a child who may not yet be infected.

See references

References for pregnancy information

  1. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. National Institute of Health "Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Available from: URL: http://aidsinfo.nih.gov/contentfiles/PerinatalGL.pdf." ([2011 Sep 14]):
  2. Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in pediatric HIV infection. Available from: URL: http://aidsinfo.nih.gov/guidelines/html/2/pediatric-treatment-guidelines/0" ([2012 Nov 5]):
  3. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  4. "Product Information. Videx (didanosine)." Bristol-Myers Squibb, Princeton, NJ.

References for breastfeeding information

  1. Fairbrothers D, Kirby E, Lester RM, Wegmann PC, Marshall F, Parkin WE "Recommendations for assisting in the prevention of perinatal transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus and AIDS." MMWR Morb Mortal Wkly Rep 34 (1985): 721-34
  2. "Product Information. Videx (didanosine)." Bristol-Myers Squibb, Princeton, NJ.
  3. Newell ML, Dunn D, Peckham CS, Ades AE, Pardi G, Semprini AE "Risk factors for mother-to-child transmission of HIV-1." Lancet 339 (1992): 1007-12
  4. "Infant feeding and transmission of human immunodeficiency virus in the United States." Pediatrics 131 (2013): 391-6
  5. Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. National Institute of Health "Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Available from: URL: http://aidsinfo.nih.gov/contentfiles/PerinatalGL.pdf." ([2011 Sep 14]):

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