Cyanocobalamin Pregnancy and Breastfeeding Warnings

Cyanocobalamin is also known as: B-12, B-12 Dots, B-12 Resin, Big Shot B-12, CaloMist, Cobal 1000, Cobolin-M, Crystal B-12, Crystamine, Crysti-12, Cyanoject, Cyomin, Depo-Cobolin, LA-12, Nascobal, Neuroforte-R, Rubesol-1000, Sytobex, Twelve Resin-K, Vibal, Vita #12, Vitabee 12, Vitamin B12

Cyanocobalamin Pregnancy Warnings

Cyanocobalamin has been assigned to pregnancy category C by the FDA. Studies have revealed a progressive decline in the maternal serum level and an increase in the urinary excretion of vitamin B12 during pregnancy. The fetus has been shown to concentrate vitamin B12 since fetal cord serum levels are approximately three times maternal values. In view of a demonstrated increase in urinary excretion of vitamin B12 during pregnancy, the recommended daily allowance (RDA) during pregnancy includes the addition of 1 mcg/day above the basal requirement of 3 mcg/day.

Cyanocobalamin Breastfeeding Warnings

In animals, vitamin B12 deficiency is associated with teratogenic effects. Methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities have been reported in breast-fed infants whose mothers were strict vegetarians. In general, severe maternal vitamin B12 deficiency may result in megaloblastic anemia with subsequent infertility and poor pregnancy outcomes. Milk concentrations are proportional to the daily intake of the vitamin. Women given daily doses of 1 to 200 micrograms/day had milk levels increase from a level of 79 pg/mL to 100 pg/mL. In a study using 8 micrograms/day of cyanocobalamin, mean milk levels of 1650 pg.mL at 1 week and 1100 pg/mL at 6 weeks were measured. Corresponding levels in unsupplemented mothers were 1220 and 610 pg./mL, respectively.

Cyanocobalamin is excreted into human milk. Cyanocobalamin is considered compatible with breast-feeding by the American Academy of Pediatrics

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)