Clonazepam Pregnancy and Breastfeeding Warnings
Clonazepam Pregnancy Warnings
This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. AU TGA pregnancy category: C US FDA pregnancy category: D Comments: -The child born to a mother taking benzodiazepines may be at risk for withdrawal symptoms. -The patient should be warned of the potential risks to the fetus and instructed to discontinue the drug prior to becoming pregnant. -There have been reports of neonatal flaccidity, respiratory and feeding difficulties, and hypothermia in children born to mothers who have been taking benzodiazepines late in pregnancy.
Animal studies have shown reproductive toxicity. There are no adequate studies in pregnant women. US: To provide information regarding the effects of in utero exposure to this drug, healthcare providers are advised to recommend that pregnant patients taking this drug enroll in the North American Anti-epileptic Drug (NAAED) Pregnancy Registry. Patients can call the toll-free number 1-888-233-2334. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Clonazepam Breastfeeding Warnings
A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes Comments: The effects in the nursing infant are unknown.
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