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Clonazepam Pregnancy and Breastfeeding Warnings

Clonazepam is also known as: Klonopin, Klonopin Wafer

Clonazepam Pregnancy Warnings

Clonazepam has been assigned to pregnancy category D by the FDA. An increased risk of congenital malformations in humans has been associated with use of all known anticonvulsant agents in the treatment of women with epilepsy. However, epilepsy itself may be associated with an increased risk of congenital malformations. Additionally, use of other benzodiazepines is associated with an increased risk in congenital malformations. Only very limited experience with the use of clonazepam during pregnancy has been reported. Some reports have suggested that clonazepam may possess less teratogenic potential than other anticonvulsants and benzodiazepines, however, there are no controlled data in human pregnancy. One report has indicated that clonazepam may cause neonatal apnea. Clonazepam should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

To provide information regarding the effects of in utero exposure to clonazepam, physicians are advised to recommend that pregnant patients taking clonazepam enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This can be done by calling the toll free number 1-888-233-2334, and must be done by patients themselves. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/.

Clonazepam Breastfeeding Warnings

Clonazepam is excreted into human milk in small amounts. No adverse effects have been reported in nursing infants, but experience is quite limited. The American Academy of Pediatrics has no position on the use of clonazepam during breast-feeding but describes other benzodiazepines as drugs "whose effect on nursing infants is unknown but may be of concern".

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