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Cidofovir Pregnancy and Breastfeeding Warnings

Cidofovir is also known as: Vistide

Cidofovir Pregnancy Warnings

Cidofovir has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryotoxicity and fetal harm at doses that are maternally toxic. In addition, animal studies have shown that cidofovir caused reduced testes weight and hypospermia. Such changes may occur in humans and cause infertility. Cidofovir has also been show to be carcinogenic and teratogenic in animal studies. There are no controlled data in human pregnancy. Women of childbearing potential should practice effective contraception during and for one month following discontinuation of treatment with cidofovir. The manufacturer recommends that men use barrier method birth control during and for at least 90 days following discontinuation of cidofovir therapy. Cidofovir should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Cidofovir Breastfeeding Warnings

There are no data on the excretion of cidofovir into human milk. However, the manufacturer considers cidofovir use to be contraindicated during lactation. In addition, HIV-infected mothers should not breast-feed their infants due to the risk of transmission of HIV via breast milk.

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