Chlorhexidine topical Pregnancy and Breastfeeding Warnings

Chlorhexidine topical is also known as: Bactoshield, Betasept, Biopatch, Calgon Vesta, Chlorostat, Chlorostat 4, Denti-Rinse, Dyna-Hex, Exidine, Hibiclens, Hibistat, Hibistat Towelette, Peridex, PerioChip, Periogard, Perisol, Scrub Care, Spectrum-4

Chlorhexidine topical Pregnancy Warnings

Chlorhexidine oral rinse has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity when given at high doses. There are no controlled data in human pregnancy. Chlorhexidine oral rinse should only be used during pregnancy when need has been clearly established. Chlorhexidine chips have been assigned to pregnancy category C by the FDA. Animal studies have not been conducted with this dosage form; however, high dosages administered by gavage were not associated with fetotoxicity. There are no controlled data in human pregnancy. Chlorhexidine absorption is possible following periodontal insertion; in clinical trials systemic chlorhexidine levels were below the limit of detection. Chlorhexidine chips should only be used during pregnancy when need has been clearly established.

Chlorhexidine topical Breastfeeding Warnings

One infant experienced episodes of bradycardia and cyanotic spells which may have been due to the application of chlorhexidine directly onto the mother's breast during breast-feeding. Chlorhexidine was detected in the blood of the infant.

There are no data on the excretion of chlorhexidine into human milk when given as an oral rinse. Some studies have reported that any chlorhexidine ingested is poorly absorbed; therefore, excretion into breast milk is unlikely. The manufacturer recommends that caution be used when administering chlorhexidine to nursing women.

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