Cetirizine/pseudoephedrine Pregnancy and Breast Feeding Warnings
Cetirizine/pseudoephedrine is also known as: All Day Allergy-D, Zyrtec-D, Zyrtec-D 12 Hour
Overview
If you become pregnant, discuss with your doctor the benefits and risks of using Cetirizine/Pseudoephedrine during pregnancy. Cetirizine/Pseudoephedrine is excreted in breast milk. Do not breast-feed while taking Cetirizine/Pseudoephedrine .
Cetirizine/pseudoephedrine Pregnancy Warnings
Cetirizine has been assigned to pregnancy category B by the FDA. High dose animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Cetirizine is only recommended for use during pregnancy when need has been clearly established. Pseudoephedrine has not been officially assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancy. Pseudoephedrine is only recommended for use during pregnancy when benefit outweighs risk.
Cetirizine/pseudoephedrine Lactation Warnings
Cetirizine is excreted into human milk. Cetirizine is considered contraindicated during breast-feeding by the manufacturer. Pseudoephedrine is excreted into human milk. Three mothers given pseudoephedrine demonstrated milk concentrations consistently higher than plasma concentrations. Maximum milk concentrations were reached at 1 to 1.5 hours after dosing. In one woman, the milk:plasma concentration ratio at 1, 3, and 12 hours was 3.3, 3.9, and 2.6. The authors calculated that 1000 mL of breast milk consumed over 24 hours would provide an infant with 0.25 to 0.33 mg of pseudoephedrine, or 0.5% to 0.7% of the dose ingested by the mother. There are no reports of adverse effects in infants who were exposed to pseudoephedrine in breast milk. Pseudoephedrine is considered compatible with breast-feeding by the American Academy of Pediatrics.
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