Caffeine / ergotamine Pregnancy and Breastfeeding Warnings
Caffeine / ergotamine Pregnancy Warnings
Caffeine-ergotamine has been assigned to pregnancy category X by the FDA. There are no studies on the placental transfer or teratogenicity of the combined product caffeine-ergotamine. Caffeine has been reported to cross the placenta and to be teratogenic in animals. Ergotamine crosses the placenta in small amounts but has not appeared to be embryotoxic in this quantity. However, prolonged vasoconstriction of the uterine vessels and/or increased myocardial tone leading to reduced myometrial and placental blood flow may have contributed to fetal growth retardation observed in animals. There are no controlled data in human pregnancy. Caffeine-ergotamine use is considered contraindicated during pregnancy.
Caffeine / ergotamine Breastfeeding Warnings
Ergotamine is excreted into human milk. Vomiting, diarrhea and convulsions have been reported in nursing infants. Ergotamine is considered contraindicated during breast-feeding by the American Academy of Pediatrics. Caffeine is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely. However, irritability and poor sleep patterns have been reported in nursing infants. The amount of caffeine generally found in caffeinated beverages is considered to usually be compatible with breast-feeding by the American Academy of Pediatrics. Because caffeine is excreted into human milk and because caffeine is metabolized slowly by nursing infants, consumption of more than moderate levels of caffeine by nursing mothers is not recommended.
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