Bevacizumab Pregnancy and Breastfeeding Warnings

Bevacizumab is also known as: Avastin

Bevacizumab Pregnancy Warnings

Angiogenesis is critical to fetal development and the inhibition of angiogenesis following administration of bevacizumab is likely to result in adverse effects on pregnancy. Patients who discontinue bevacizumab should also be counseled concerning the prolonged exposure following discontinuation of therapy (half-life approximately 20 days) and the possible effects on fetal development. The incidence of ovarian failure was higher (34% vs. 2%) in premenopausal women receiving bevacizumab in combination with mFOLFOX chemotherapy as compared to those receiving mFOLFOX chemotherapy alone for adjuvant treatment for colorectal cancer, a use for which bevacizumab is not approved. Inform females of reproductive potential of the risk of ovarian failure prior to starting treatment with bevacizumab.

Bevacizumab has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Bevacizumab should only be given during pregnancy when benefits outweigh risks.

Bevacizumab Breastfeeding Warnings

There are no data on the excretion of bevacizumab into human milk. Human IgG1 is secreted into human milk. The potential for absorption and harm to the infant after ingestion is unknown. Women should be advised to discontinue nursing during treatment with bevacizumab and for a prolonged period following therapy with bevacizumab, taking into account that the half-life averages approximately 20 days.

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