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Bevacizumab Pregnancy and Breastfeeding Warnings

Bevacizumab is also known as: Avastin

Bevacizumab Pregnancy Warnings

-Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. -Bevacizumab could impair female fertility. Fertility preservation methods should be discussed with women of child bearing potential before initiation of treatment. AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

UK: Contraindicated AU, US: This drug should not be used during pregnancy unless the benefit outweighs the risk to the fetus. AU TGA pregnancy category: D US FDA pregnancy category: C Comments: -Women of childbearing potential should use contraception during therapy and for 6 months following the last dose.

Bevacizumab Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Unknown Comments: -Women should discontinue breast-feeding during therapy and not breast-feed for at least six months following the last dose. -Human IgG1 is secreted into human milk. The potential for absorption and harm to the infant after ingestion is unknown.

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