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Betamethasone Pregnancy and Breastfeeding Warnings

Betamethasone is also known as: Adbeon, Beta-Phos/AC, Celestone, Celestone Phosphate, Celestone Soluspan, Cell-U-Jec, Selestoject

Betamethasone Pregnancy Warnings

Betamethasone has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity when corticosteroids are administered orally or potent steroids are applied topically. Betamethasone has been shown to be teratogenic when administered intramuscularly to rabbits. There are no controlled data in human pregnancy. Betamethasone has been shown to cross the placenta. Betamethasone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

See references

Betamethasone Breastfeeding Warnings

There are no data on the excretion betamethasone into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Sybulski S "Effect of antepartum betamethasone treatment on cortisol levels in cord plasma, amniotic fluid, and the neonate." Am J Obstet Gynecol 127 (1977): 871-4
  2. Derks JB, Mulder EJH, Visser GHA "The effects of maternal betamethasone administration on the fetus." Br J Obstet Gynaecol 102 (1995): 40-6
  3. Ballard RA, Ballard PL "Use of prenatal glucocorticoid therapy to prevent respiratory distress syndrome. A supporting view." Am J Dis Child 130 (1976): 982-7
  4. Anderson AB, Gennser G, Jeremy JY, Ohrlander S, Sayers L, Turnbull AC "Placental transfer and metabolism of betamethasone in human pregnancy." Obstet Gynecol 49 (1977): 471-4
  5. Maltau JM, Stokke KT, Moe N "Effects of betamethasone on plasma levels of estriol, cortisol and HCS in late pregnancy." Acta Obstet Gynecol Scand 58 (1979): 235-8
  6. Petersen MC, Nation RL, Ashley JJ, McBride WG "The placental transfer of betamethasone." Eur J Clin Pharmacol 18 (1980): 245-7
  7. Ohrlander S, Gennser G, Batra S, Lebech P "Effect of betamethasone administration on estrone, estradiol-17 beta, and progesterone in maternal plasma and amniotic fluid." Obstet Gynecol 49 (1977): 148-53
  8. "Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.
  9. Kuhn RJ, Speirs AL, Pepperell RJ, Eggers TR, Doyle LW, Hutchison A "Betamethasone, albuterol, and threatened premature delivery: benefits and risks. Study of 469 pregnancies." Obstet Gynecol 60 (1982): 403-8

References for breastfeeding information

  1. "Product Information. Celestone (betamethasone)." Schering Corporation, Kenilworth, NJ.

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