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Benztropine Pregnancy and Breastfeeding Warnings

Benztropine is also known as: Cogentin

Benztropine Pregnancy Warnings

Benztropine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in animal or human pregnancy. Benztropine is only recommended for use during pregnancy when need has been clearly established and benefit outweighs the risk.

In a large prospective study of 2323 exposures during the first trimester, atropine-related drugs as a whole were possibly associated with minor fetal malformations. However, only 4 of those exposures were to benztropine. A surveillance study of Michigan Medicaid recipients recorded 84 newborns exposed to benztropine during the first trimester between 1985 and 1992. Four major birth defects were noted (three expected). Three were cardiovascular defects (one expected), suggesting a possible association with benztropine exposure. Paralytic ileus has been reported in 2 newborns exposed to chlorpromazine and benztropine. In one case, other anticholinergic agents had also been administered to the mother. The condition resolved rapidly in both infants following a Gastrografin enema.

Benztropine Breastfeeding Warnings

There are no data on the excretion of benztropine into human milk.

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