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Amphotericin b Pregnancy and Breastfeeding Warnings

Amphotericin b is also known as: Amphocin, Fungizone, Fungizone For Tissue Culture

Amphotericin b Pregnancy Warnings

Amphotericin B crosses the human placenta, with cord blood to maternal serum drug concentration ratios averaging up to 1.0. There were no reports of adverse fetal effects or congenital defects associated with amphotericin B in the Collaborative Perinatal Project. This study was a retrospective analysis of 50,282 mother-child pairs, 9 of whom experienced first trimester exposure to amphotericin B.

Amphotericin B has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Amphotericin B should only be given during pregnancy when benefit outweighs risk.

Amphotericin b Breastfeeding Warnings

There are no data on the excretion of amphotericin B into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from amphotericin B, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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