Tetanus Immune Globulin( TIG )
Pronunciation: TET-ah-nus ih-MYOON GLAH-byoo-lin
Class: Immune globulin
- Solution 250 units/syringe
Directly neutralizes toxin excreted by Clostridium tetani , cause of tetanus.
Tetanus immune globulin T max is approximately 2 days after IM injection.
Tetanus immune globulin T ½ is 23 days.
Indications and Usage
Passive, transient protection against tetanus in any person that may be contaminated with tetanus spores when: (1) patient's personal history of immunization with tetanus toxoid is unknown or uncertain, (2) person received less than 2 prior doses of tetanus toxoid, or (3) person received 2 prior doses of tetanus toxoid, but delay of more than 24 h occurred between time of injury and initiation of tetanus prophylaxis.
Treatment of clinical tetanus.
Hypersensitivity to human antibody product, thimerosal, or other components; circulating anti-IgA antibodies.
Dosage and AdministrationAdults Prophylactic dose
IM 250 units. Give 500 units if wounds are severe or treatment is delayed. Dosage may be increased to 1,000 to 2,000 units. For therapy of tetanus, give 500 to 3,000 or 6,000 units. Give deep IM, preferably in upper outer quadrant of gluteal muscle.Children
IM Dose is calculated on basis of body weight (4 units/kg); however, it may be advisable to administer 250 units regardless of the size of the child. The same amount of toxin is produced by the bacteria in adults and children.
- Refer to appropriate immunization schedule or CDC wound management guideline for correct dosing.
- Use different syringe and injection site for the tetanus toxoid.
Store in the refrigerator.
There is no significant interaction between TIG and tetanus toxoid if given at different injection sites. To avoid inactivating vaccines containing live viruses or bacteria, give live vaccines 2 to 4 wk before or 12 wk after TIG.
Laboratory Test Interactions
None well documented.
Local and systemic reactions following TIG are infrequent and usually mild. Expect some pain, tenderness, and muscle stiffness at injection site, persisting for several hours. Hives, angioedema, nephrotic syndrome, and local inflammation occur occasionally. Anaphylactic reactions are very infrequent.
Category C .
Undetermined. Use TIG as soon as possible after tetanus-prone injuries. Do not inject IV.
- Alert patient that pain, soreness, inflammation, or stiffness at site of injection may be experienced.
- Advise patient who is also receiving tetanus toxoid series to complete pending immunizations since TIG protection is only temporary.
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