Pronunciation: mag-NEE-zee-uhm OX-ide
- Tablets 400 mg
- Tablets 420 mg
- Capsules 140 mg
Neutralizes gastric acid, thereby increases pH of stomach and duodenal bulb; also increases lower esophageal sphincter tone.
Magnesium Oxide is eliminated renally and fecally.
Duration is 4 to 6 h.
Indications and Usage
Symptomatic relief of upset stomach associated with hyperacidity, including heartburn, gastroesophageal reflux, acid indigestion and sour stomach; relief of hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, gastric hyperacidity and hiatal hernia. Also used for treatment of hypomagnesemia, or magnesium depletion resulting from malnutrition, restricted diet, alcoholism or magnesium-depleting drugs.
Dosage and AdministrationAdults
PO 140 mg (caps) 3 to 4 times/day or 400 to 840 mg/day (tabs).
Store at room temperature.
Decreased pharmacological effect of iron.Nitrofurantoin
Decreased pharmacological effect of nitrofurantoin.Penicillamine
Decreased pharmacological effect of penicillamine.Tetracyclines
Decreased pharmacological effect of tetracyclines.
Laboratory Test Interactions
None well documented.
Laxative effect (diarrhea); rebound hyperacidity.
Category B .
Use caution in patients with renal function impairment to avoid hypermagnesemia and toxicity.
Diarrhea, fluid and electrolyte abnormalities, hypermagnesemia.
- Advise patient that drug may be laxative and cause diarrhea.
- If being used for antacid effect, instruct patient to notify health care provider if symptoms are not relieved or if black, tarry stools or “coffee-ground” vomitus occurs. These symptoms can indicate bleeding.
- Explain that drug should not be used routinely for laxative effect. Advise patient to use other forms of bowel regulation such as increasing fluid intake, mobility and bulk in diet.
- Warn patient not to take other medications within 2 h of antacids.
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