Magnesium Oxide

Pronunciation

Pronunciation: mag-NEE-zee-uhm OX-ide
Class: Antacid

Trade Names

Mag-Ox 400
- Tablets 400 mg

Maox 420
- Tablets 420 mg

Uro-Mag
- Capsules 140 mg

Pharmacology

Neutralizes gastric acid, thereby increases pH of stomach and duodenal bulb; also increases lower esophageal sphincter tone.

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Pharmacokinetics

Elimination

Magnesium Oxide is eliminated renally and fecally.

Duration

Duration is 4 to 6 h.

Indications and Usage

Symptomatic relief of upset stomach associated with hyperacidity, including heartburn, gastroesophageal reflux, acid indigestion and sour stomach; relief of hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, gastric hyperacidity and hiatal hernia. Also used for treatment of hypomagnesemia, or magnesium depletion resulting from malnutrition, restricted diet, alcoholism or magnesium-depleting drugs.

Contraindications

Standard considerations.

Dosage and Administration

Adults

PO 140 mg (caps) 3 to 4 times/day or 400 to 840 mg/day (tabs).

Storage/Stability

Store at room temperature.

Drug Interactions

Iron

Decreased pharmacological effect of iron.

Nitrofurantoin

Decreased pharmacological effect of nitrofurantoin.

Penicillamine

Decreased pharmacological effect of penicillamine.

Tetracyclines

Decreased pharmacological effect of tetracyclines.

Laboratory Test Interactions

None well documented.

Adverse Reactions

GI

Laxative effect (diarrhea); rebound hyperacidity.

Metabolic

Hypermagnesemia.

Miscellaneous

Milk-alkali syndrome.

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Renal Function

Use caution in patients with renal function impairment to avoid hypermagnesemia and toxicity.

Overdosage

Symptoms

Diarrhea, fluid and electrolyte abnormalities, hypermagnesemia.

Patient Information

  • Advise patient that drug may be laxative and cause diarrhea.
  • If being used for antacid effect, instruct patient to notify health care provider if symptoms are not relieved or if black, tarry stools or “coffee-ground” vomitus occurs. These symptoms can indicate bleeding.
  • Explain that drug should not be used routinely for laxative effect. Advise patient to use other forms of bowel regulation such as increasing fluid intake, mobility and bulk in diet.
  • Warn patient not to take other medications within 2 h of antacids.

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