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Ketotifen Fumarate

Pronunciation: KEY-toe-TIF-fen FEW-mah-rate
Class: Ophthalmic antihistamine

Trade Names

- Solution 0.025%

Claritin Eye
- Solution 0.025%

Itchy Eye Drops
- Solution 0.025%

- Solution 0.025%


Inhibits release of mediators from cells involved in hypersensitivity reactions.

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Little systemic exposure following topical ocular administration.

Indications and Usage

Temporary prevention of itching of eyes caused by allergic conjunctivitis.


Standard considerations.

Dosage and Administration

Adults and children 3 y of age and older

Ophthalmic 1 drop in affected eye(s) twice daily, every 8 to 12 h.

General Advice

  • For topical ophthalmic use only. Not for use on the skin, in the ear, or for injection into eye.
  • Ask patient to tilt head back and instill prescribed number of drops into affected eye(s) as ordered. Ask patient to close eye(s) for 2 to 3 min and apply light finger pressure to lacrimal sac for 1 to 2 min after installation. Do not touch top of dropper bottle to eye, fingers, or any other surface.
  • If using other topical ophthalmic medications, separate each medication by at least 5 min. Instill ophthalmic ointment last.


Store ophthalmic solution between 39° and 77°F. Keep tightly capped.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Headache (10% to 25%).


Conjunctival injection, rhinitis (10% to 25%); ocular allergic reactions, burning or stinging of eye, conjunctivitis, eye discharge, dry eye, eye pain, eyelid disorder, itching eye, keratitis, lacrimation disorder, mydriasis, photophobia, rash, pharyngitis (less than 5%).


Flu syndrome (less than 5%).



Category C .




Safety and efficacy not established in children younger than 3 y of age.

Patient Information

  • Remind patient that eye drops are for use in the eye only.
  • Teach patient proper technique for instilling eye drops: Wash hands; do not allow dropper to touch eye; tilt head back and look up; pull lower eyelid down; instill prescribed number of drops; close eye for 1 to 2 min and apply gentle pressure to bridge of nose for 1 to 3 min; do not rub eye.
  • Caution patient not to touch top of dropper bottle to eye, fingers, or any other surface.
  • Advise patient that if more than 1 topical ophthalmic medication is being used to separate each medication by at least 5 min apart. Instill ophthalmic ointment last.
  • Inform patient that eye redness, headaches, and runny nose are the most common side effects and to contact health care provider if they occur and are bothersome.
  • Advise patient to contact eye doctor if eye or eyelid inflammation is noted or if eye symptoms do not improve or worsen.
  • Instruct patient wearing contact lenses to remove lenses when instilling eye drops and, if wearing soft contact lenses, to wait 10 min after instilling drops before inserting lenses.
  • Caution patient wearing contact lenses not to wear lenses if eyes are red.

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