Ketotifen ophthalmic Side Effects

Not all side effects for ketotifen ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ketotifen ophthalmic: oral syrup, oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by ketotifen ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ketotifen ophthalmic, check with your doctor or nurse as soon as possible:

Less common
  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Rare
  • Abdominal or stomach pain
  • blistering, itching, peeling, or redness of skin
  • bloody or cloudy urine
  • clay-colored stools
  • convulsions
  • dark urine
  • difficult, burning, or painful urination
  • dizziness
  • frequent urge to urinate
  • muscle spasm or jerking of all extremities
  • rash
  • sudden loss of consciousness
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin
Symptoms of overdose

If any of the following symptoms of overdose occur while taking ketotifen ophthalmic, get emergency help immediately:

  • Blurred vision
  • confusion
  • convulsions
  • disorientation
  • dizziness
  • drowsiness (severe)
  • faintness or lightheadedness when getting up from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • hyperexcitability
  • loss of consciousness
  • palpitations
  • sweating
  • unusual tiredness or weakness

Some of the side effects that can occur with ketotifen ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Weight gain
Less common or rare
  • Bloody nose
  • drowsiness
  • dryness of mouth
  • excitation
  • increased appetite
  • irritability
  • nervousness
  • swelling of eyelids
  • unexplained nosebleeds

For Healthcare Professionals

Applies to ketotifen ophthalmic: ophthalmic solution

Ocular

Ocular side effects have included conjunctival congestion (10% to 25%). There was a significant underlying incidence of conjunctival congestion among treated patients and a causal relationship with use of ketotifen has not been established. Other ocular side effects have included burning or stinging, conjunctivitis, ocular discharge, dry eyes, eyelid disorder, eye pain, itching, keratitis, lacrimation disorder, mydriasis, photophobia, and local rash (< 5%).[Ref]

Ketotifen instillation was associated with mild to moderate burning or stinging in 98% of patients (n=35) in one trial.[Ref]

Nervous system

Nervous system side effects including headache have been reported in up to 25% of patients. However, there has been no distinction between headache due to underlying disease and use of the drug such that a causal relationship has been questioned. Headaches associated with the use of this product have generally been mild.[Ref]

Respiratory

Respiratory side effects have included rhinitis (25%). Other respiratory side effects have included pharyngitis (5%).[Ref]

General

General side effects have included flu syndrome (5%).[Ref]

References

1. Yanni JM, Stephens DJ, Miller ST, Weimer LK, Graff G, Parnell D, Lang LS, Spellman JM, Brady MT, Gamache DA "The in vitro and in vivo ocular pharmacology of olopatadine (AL- 4943A), an effective anti-allergic/antihistaminic agent." J Ocul Pharmacol Ther 12 (1996): 389-400

2. Artal MN, Luna JD, Discepola M "A forced choice comfort study of olopatadine hydrochloride 0.1% versus ketotifen fumarate 0.05%." Acta Ophthalmol Scandinavica 78 (2000): 64-5

3. "Product Information. Zaditor (ketotifen ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web4)