Class: General anesthetic
- Injection, solution 2 mg/mL
Etomidate is an anesthetic without analgesic activity.
Rapidly metabolized in the liver, primarily by hydrolysis.
Elimination half-life about 75 min. Approximately 75% eliminated in the urine within 24 h.
Usually within 1 min.
3 to 5 min.
Special PopulationsRenal Function Impairment
Appears to have no effect on etomidate pharmacokinetics.Hepatic Function Impairment
Vd increases 2-fold in patients with cirrhosis compared with healthy subjects.Elderly
Vd, total Cl, and plasma protein binding are decreased in elderly patients.
Indications and Usage
Induction of general anesthesia; supplementation of subpotent anesthetic agents (eg, nitrous oxide) during maintenance of anesthesia for short operative procedures.
Dosage and AdministrationAdults and Children 10 yr of age and older
IV The dose must be individualized in each case. The dose varies between 0.2 and 0.6 mg/kg (usual dose, 0.3 mg/kg) injected over a period of 30 to 60 sec. Elderly patients may require reduced doses.
- Etomidate is compatible with commonly administered preanesthetic medications.
- Not intended for prolonged infusion.
- Do not administer unless the solution is clear and the container is undamaged.
- Discard unused portion.
Store at 59° to 86°F.
None well documented.
Laboratory Test Interactions
None well documented.
Transient venous pain (20%); arrhythmias; bradycardia; hypertension; hypotension; tachycardia.
Postoperative nausea and/or vomiting.
Transient skeletal muscle movements, including myoclonic, averting, tonic, and eye movements (32%).
Apnea of 5- to 90-sec duration; hiccup; hyperventilation; hypoventilation; laryngospasm; snoring.
Monitor renal function in elderly patients. Monitor plasma cortisol and aldosterone levels during induction.
Category C .
Safety and efficacy not established in children younger than 10 yr of age.
May induce cardiac depression in elderly patients, especially in patients with hypertension. Because renal function may be reduced in elderly patients, select dose with caution.
Because etomidate is excreted primarily by the kidney, the risk of toxicity may be increased in patients with renal function impairment.
Administering an injection too rapidly may result in a fall in BP. No CV or respiratory effects have been attributed to an overdosage.
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