Radiogardase

Generic Name: Prussian blue (PRUSH an BLOO)
Brand Name: Radiogardase

What is Radiogardase (Prussian blue)?

Prussian blue was originally developed as a dye for use in paints and ink. It is used in medicine to help speed up the body's elimination of certain metals or chemical elements. It works by binding to the metals in the digestive tract to keep the body from absorbing them.

Prussian blue is used to treat people who have been contaminated with radioactive cesium or thallium, or non-radioactive thallium.

Prussian blue may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Radiogardase (Prussian blue)?

Before you take Prussian blue, tell your doctor if you have a digestive disorder, chronic constipation, a blockage in your stomach or intestines, a heart rhythm disorder; or an electrolyte imbalance.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Prussian blue is usually taken 3 times per day for at least 30 days.

Prussian blue may work best if you take it with food.

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After you are treated with Prussian blue, your urine and stools will contain the radioactive materials that the medication has helped the body eliminate.

Avoid handling any clean-up of your stools or urine without wearing latex rubber gloves. If another person is handling your stools or urine, they should wear gloves, eye protection, and a mask to cover the nose and mouth.

Prussian blue may cause your stools to appear blue in color. This is a normal side effect of Prussian blue, and should not be cause for alarm.

Although Prussian blue helps the body quickly eliminate a radioactive element, this medication will not treat any symptoms of radiation exposure. You will be given other medications to treat complications of radiation exposure, such as bone marrow suppression or severe infection.

While taking Prussian blue, tell your caregivers at once if you have a serious side effect such as severe constipation or stomach pain.

Prussian blue may bind with other medications and could possibly make them less effective. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors.

What should I discuss with my health care provider before taking Radiogardase (Prussian blue)?

Before you take Prussian blue, tell your doctor if you are allergic to any drugs, or if you have:

  • a digestive disorder;

  • chronic constipation;

  • a blockage in your stomach or intestines;

  • a heart rhythm disorder; or

  • an electrolyte imbalance.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use Prussian blue.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant before you are treated with Prussian blue.

It is not known whether Prussian blue passes into breast milk or if it could harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

Exposure to radiation could cause a man to have low sperm counts up to several years later. Talk with your doctor if you have concerns about how radiation may affect your fertility.

How should I take Radiogardase (Prussian blue)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Prussian blue may work best if you take it with food.

Prussian blue is usually taken 3 times per day for at least 30 days. You may need to take several capsules at one time to get the correct dose.

If you are unable to swallow large number of capsules, you may open the capsules and sprinkle the medicine into a small amount of liquid or bland food to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

Opening a Prussian blue capsule and mixing the medicine with liquid or food may cause a blue discoloration inside your mouth.

After you are treated with Prussian blue, your urine and stools will contain the radioactive materials that the medication has helped the body eliminate.

Use a toilet rather than a urinal and sit on the toilet while urinating. Flush the toilet 3 times with the lid down after use.

Always wash your hands after using the bathroom.

Avoid handling any clean-up of your stools or urine without wearing latex rubber gloves. If another person is handling your stools or urine, they should wear gloves, eye protection, and a mask to cover the nose and mouth.

When cleaning any spills of bodily fluid, use only disposable cleaning cloths that can be flushed down a toilet. Ask your doctor or health department how to dispose of any bodily fluid spills that cannot be flushed down a toilet.

Wash any soiled clothing separately from the laundry of other people in your home.

Prussian blue may cause your stools to appear blue in color. This is a normal side effect of Prussian blue, and should not be cause for alarm.

Although Prussian blue helps the body quickly eliminate a radioactive element, this medication will not treat any symptoms of radiation exposure. You will be given other medications to treat complications of radiation exposure, such as bone marrow suppression or severe infection.

To be sure this medication is helping your condition, the radiation levels in your urine and stools will need to be checked often. This will help your doctor determine how long to treat you with Prussian blue. Do not miss any scheduled appointments.

Store Prussian blue capsules in the dark at room temperature.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe constipation, thirst, drowsiness, confusion, increased urination, muscle pain or weakness, feeling light-headed, or fainting.

What should I avoid while taking Radiogardase (Prussian blue)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking Prussian blue.

Radiogardase (Prussian blue) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as severe constipation or stomach pain.

Less serious side effects may include mild constipation or minor stomach discomfort.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Radiogardase (Prussian blue)?

Prussian blue may bind with other medications and could possibly make them less effective.

Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More about Radiogardase (prussian blue)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Prussian blue.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.04. Revision Date: 2010-12-15, 5:01:39 PM.

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