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ertapenem

Pronunciation

Generic Name: ertapenem (er ta PEN em)
Brand Name: INVanz, INVanz ADD-Vantage

What is ertapenem?

Ertapenem is an antibiotic that fights bacteria.

Ertapenem is used to treat severe infections of the skin, lungs, stomach, pelvis, and urinary tract. It is also used to prevent infection in people having certain types of surgery.

Ertapenem may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ertapenem?

You should not use this medicine if you are allergic to certain antibiotics. You should not inject ertapenem into a muscle if you are allergic to a numbing medicine such as lidocaine or Novocain.

Slideshow: Flashback: FDA Drug Approvals 2013

What should I discuss with my healthcare provider before using ertapenem?

You should not use this medicine if you are allergic to ertapenem or to certain antibiotics, especially:

  • meropenem (Merrem);

  • imipenem (Primaxin);

  • a cephalosporin such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others; or

  • an antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).

You should not inject ertapenem into a muscle if you are allergic to a numbing medicine such as lidocaine or Novocain.

To make sure ertapenem is safe for you, tell your doctor if you have:

  • kidney disease;

  • epilepsy or other seizure disorder; or

  • a history of head injury or brain tumor.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ertapenem can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to a child younger than 3 months old.

How should I use ertapenem?

Ertapenem is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

Ertapenem is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine. Shake the mixture well just before you measure a dose.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ertapenem will not treat a viral infection such as the flu or a common cold.

Do not share this medicine with another person, even if they have the same symptoms you have.

Your doctor will need to check your progress while you are using ertapenem.

Store ertapenem powder at room temperature away from moisture and heat.

You may store the mixture for up to 6 hours at room temperature, or up to 24 hours in a refrigerator. Use the mixed medicine within 4 hours after removing it from a refrigerator. Do not freeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using ertapenem?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ertapenem side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • tremors, twitching, or rigid (very stiff) muscles;

  • a seizure (convulsions); or

  • unusual changes in your mood or behavior.

Common side effects include:

  • nausea, vomiting;

  • diarrhea;

  • headache; or

  • pain, redness, or mild swelling where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ertapenem dosing information

Usual Adult Dose for Intraabdominal Infection:

Complicated: 1 gram IV or IM once daily for 5 to 14 days

Usual Adult Dose for Pelvic Infections:

1 gram IV or IM once daily for 3 to 10 days

Usual Adult Dose for Pneumonia:

Community-acquired: 1 gram IV or IM once daily
The recommended total duration of antibiotic treatment is 10 to 14 days, which includes a possible conversion to oral therapy after at least 3 days of parenteral therapy and once clinical improvement occurs.

Usual Adult Dose for Pyelonephritis:

1 gram IV or IM once daily
The recommended total duration of antibiotic treatment is 10 to 14 days, which includes a possible conversion to oral therapy after at least 3 days of parenteral therapy and once clinical improvement occurs.

Usual Adult Dose for Skin or Soft Tissue Infection:

Complicated: 1 gram IV or IM once daily for 7 to 14 days
The recommended total duration of antibiotic treatment for diabetic foot infections without osteomyelitis is up to 28 days, which includes a possible conversion to oral therapy.

Usual Adult Dose for Urinary Tract Infection:

Complicated: 1 gram IV or IM once daily
The recommended total duration of antibiotic treatment is 10 to 14 days, which includes a possible conversion to oral therapy after at least 3 days of parenteral therapy and once clinical improvement occurs.

Usual Adult Dose for Infection Prophylaxis:

Prophylaxis of surgical site infection following elective colorectal surgery: 1 gram IV one time, one hour prior to surgical incision

Usual Pediatric Dose for Intraabdominal Infection:

Complicated infection:
3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or older: 1 gram IV or IM once daily

Duration: 5 to 14 days

Usual Pediatric Dose for Pelvic Infections:

3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or older: 1 gram IV or IM once daily

Duration: 3 to 10 days

Usual Pediatric Dose for Pneumonia:

Community-acquired:
3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or older: 1 gram IV or IM once daily

Duration: 10 to 14 days

Usual Pediatric Dose for Pyelonephritis:

3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or more: 1 gram IV or IM once daily

Duration: 10 to 14 days

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Complicated:
3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or older: 1 gram IV or IM once daily

Duration: 7 to 14 days

Usual Pediatric Dose for Urinary Tract Infection:

Complicated:
3 months to 12 years: 15 mg/kg IV or IM every 12 hours
Maximum dose: 1 g/day

13 years or more: 1 gram IV or IM once daily

Duration: 10 to 14 days

What other drugs will affect ertapenem?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • divalproex (Depakote);

  • valproic acid (Depakene); or

  • probenecid (Benemid).

This list is not complete. Other drugs may interact with ertapenem, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about ertapenem.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Revision Date: 2015-02-03, 1:47:30 PM.

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