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Can you drink alcohol while taking Skyrizi?

Medically reviewed by Philip Thornton, DipPharm. Last updated on June 23, 2022.

Official answer

by Drugs.com

Skyrizi (risankizumab-rzaa) is a medication used to treat adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy, as well as adults with active psoriatic arthritis or moderately-to-severely active Crohn's disease. Skyrizi is not known to interact with alcohol and there is no warning in the drug’s Product Label against drinking alcohol while receiving Skyrizi.

While drinking alcohol isn’t contraindicated while Skyrizi is being used as a treatment, alcohol consumption is known to be higher in people with psoriasis than the general population and drinking alcohol can worsen the symptoms of psoriasis. People with psoriasis may benefit from limiting or avoiding alcohol. Alcohol consumptions should also be limited or avoided in people with Crohn's disease if if causes symptoms to flare up.

References
  • Food and Drug Administration (FDA). Skyrizi. April 2021. [Accessed June 23, 2022]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/761262s000lbl.pdf.
  • Brenaut E, Horreau C, Pouplard C, et al. Alcohol consumption and psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol. 2013;27 Suppl 3:30-35. doi:10.1111/jdv.12164.
  • Szentkereszty-Kovács Z, Gáspár K, Szegedi A, Kemény L, Kovács D, Törőcsik D. Alcohol in Psoriasis-From Bench to Bedside. Int J Mol Sci. 2021;22(9):4987. Published 2021 May 7. doi:10.3390/ijms22094987.
  • Piovezani Ramos G, Kane S. Alcohol Use in Patients With Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2021;17(5):211-225.

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For both plaque psoriasis and psoriatic arthritis, you’ll receive your first two starter doses of Skyrizi four weeks apart, then you’ll have an injection every 12 weeks thereafter (4 maintenance doses per year). For Crohn's disease, you'll receive 3 starter doses given into a vein 4 weeks apart (Week 0, 4 and 8) at a healthcare facility, then a subcutaneous (under the skin) injection given at Week 12, followed by an injection using a prefilled cartridge with an on-body injector every 8 weeks thereafter (6 maintenance doses per year). Continue reading

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