How is Tzield administered?
Tzield is given by intravenous infusion over a minimum of 30 minutes once daily for 14 consecutive days. Dosage is based on body surface area and increases as follows:
- Day 1: 65 mcg/m2
- Day 2: 125 mcg/m2
- Day 3: 250 mcg/m2
- Day 4: 500 mcg/m2
- Days 5 through 14: 1,030 mcg/m2.
Tzield needs to be diluted before administration and patients should be premedicated with an NSAID or acetaminophen, an antihistamine, and/or an antiemetic, approximately one hour before administration of the infusion for at least the first 5 days of the infusion.
Only one dose should be administered per day. If a dose is missed, just resume the remaining doses on consecutive days to complete the 14-day treatment course.
References
- Tzield Injection Prescribing Information. Updated 11/2022. Provention Bio, Inc. https://www.drugs.com/pro/tzield-injection.html
- FDA Approves First Drug That Can Delay Onset of Type 1 Diabetes. November 17, 2022. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-can-delay-onset-type-1-diabetes
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