How effective is Tzield?
Tzield has been shown to delay the progression of Stage 2 type 1 diabetes to Stage 3 type 1 diabetes by 25 months (approximately 2 years) in a phase 3, randomized, double-blind clinical trial. In an extended follow-up of this trial (duration 923 days), the average time to diagnosis of stage 3 type 1 diabetes was 59.6 months for Tzield-treated patients compared with 27.1 months for patients given a placebo (a difference of 32.5 months).
Another study that followed people for 7 years found persistent immunological responses and a reduced decline in C-peptide up to 7 years after the diagnosis of diabetes in people who respond to Tzield.
References
- Herold KC, Bundy BN, Long SA, et al.. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N Engl J Med. 2019;381(7):603–613.
- Hagopian, W., Ferry, R. J., Jr, Sherry, N., Carlin, D., Bonvini, E., Johnson, S., Stein, K. E., Koenig, S., Daifotis, A. G., Herold, K. C., Ludvigsson, J., & Protégé Trial Investigators (2013). Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protégé trial. Diabetes, 62(11), 3901–3908. https://doi.org/10.2337/db13-023
- Sims, E. K., Bundy, B. N., Stier, K., Serti, E., Lim, N., Long, S. A., Geyer, S. M., Moran, A., Greenbaum, C. J., Evans-Molina, C., Herold, K. C., & Type 1 Diabetes TrialNet Study Group (2021). Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Science translational medicine, 13(583), eabc8980. https://doi.org/10.1126/scitranslmed.abc8980
- Perdigoto, A. L., Preston-Hurlburt, P., Clark, P., Long, S. A., Linsley, P. S., Harris, K. M., Gitelman, S. E., Greenbaum, C. J., Gottlieb, P. A., Hagopian, W., Woodwyk, A., Dziura, J., Herold, K. C., & Immune Tolerance Network (2019). Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Diabetologia, 62(4), 655–664. https://doi.org/10.1007/s00125-018-4786-9
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