Does Kevzara cause weight gain?

• Weight gain is not a reported side effect of Kevzara.
• The symptoms of rheumatoid arthritis or polymyalgia rheumatica (PMR) can make people tired and make it hard for them to move and exercise, which may contribute to weight gain.
• Other drugs that may also be given for rheumatoid arthritis or PMR, such as prednisone, are more likely to cause weight gain.

Kevzara (sarilumab) is used to treat moderate to severe rheumatoid arthritis (RA) or PMR in adults. It belongs to a family of medicines called interleukin-6 (IL-6) inhibitors and is a type of biologic.

Kevazara works by blocking the effects of a protein called interleukin-6 (IL-6). IL-6 is a type of inflammatory cytokine and it is involved in several different processes within the body, including inducing the production of C-reactive protein (CRP) by the liver.

IL-6 contributes significantly to the symptoms of rheumatoid arthritis and PMR. It is found in abundance in the synovial fluid and serum of people with RA and levels of IL-6 are higher during periods of increased disease activity and joint destruction. It also contributes to other symptoms of RA, such as anemia, osteoporosis, and fatigue. IL-6 is elevated in people with PMR, and high levels correlate with disease activity and systemic inflammation.

Kevzara is usually given once every two weeks as a subcutaneous (under the skin) injection.

Weight gain has not been reported as a side effect of Kevzara. Common side effects of Kevzara include:

• Black, bloody or tarry stools
• Cough
• Difficulty urinating
• Fever
• Lower back pain
• Sore throat
• Tiredness or weakness
• Ulcers in the mouth
• Unusual bleeding or bruising.

The symptoms of rheumatoid arthritis and PMR can make people tired and make it hard for them to move and exercise, which may contribute to weight gain.

Other drugs that may also be given for rheumatoid arthritis or PMR, such as prednisone, are likely to cause weight gain.