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How is Exondys 51 administered?

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 21, 2023.

Official answer

by Drugs.com

Exondys 51 is administered once a week as a 35 to 60-minute intravenous infusion by your healthcare provider. The correct dosage of Exondys 51 is drawn up and then diluted in an infusion bag containing 0.9% sodium chloride to make a total volume of 100-150 mL. The diluted solution is then administered into one of your veins via an in-line 0.2-micron filter.

Exondys 51 is used to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 51 skipping.

References
  • EXONDYS 51 (eteplirsen) injection Label https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/206488lbl.pdf

Read next

The new drugs approved by the FDA for the treatment of Duchenne Muscular Dystrophy (DMD) are Amondys 45, Viltepso, Vyondys 53, Exondys 51, Elevidys, Emflaza and Duvyzat. They include classes such as antisense oligonucleotides, a glucocorticoid, a gene therapy and a histone deacetylase (HDAC) inhibitor. Continue reading

Exondys 51 is not technically gene therapy, but it does treat people with Duchenne muscular dystrophy who have a confirmed genetic mutation in their dystrophin gene which means they are unable to make the protein dystrophin. Dystrophin is needed for muscle repair. Without it, muscle cells become damaged and weakened over time, which can affect voluntary movement, such as walking. Continue reading

There is currently no specific age range specified for using Exondys 51, but a two-part Phase 3 study scheduled to run until 2026 has recruited boys and young men aged 4 though 21 who meet the study criteria. Previous studies have only investigated boys up to age 19 years. Symptoms of Duchenne muscular dystrophy (DMD) usually appear between 3 and 5 years of age and the condition primarily affects boys at a rate of about 1 in every 3,600 male infants born. If you have an older child, the best thing you can do is talk to your doctor about Exondys 51 treatment. Continue reading

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