Kepivance

Generic Name: palifermin (pal E fair men)
Brand Names: Kepivance

What is Kepivance?

Kepivance is a human keratinocyte growth factor (KGF) produced by recombinant DNA technology.

Kepivance is used to reduce the chance of developing sores and ulcers in the mouth and to shorten the time with sores or ulcers in patients with blood cancers who receive high doses of chemotherapy and radiation therapy before bone marrow transplants.

Kepivance may also be used for purposes other than those listed in this medication guide.

Important information

Kepivance is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Kepivance should not be given to you within 24 hours of your chemotherapy treatment.

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If you experience any of the following serious side effects from Kepivance, seek emergency medical attention or contact your doctor immediately:

  • fever;
  • breathing problems;
  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

What should I discuss with my healthcare provider before receiving Kepivance?

Kepivance is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Kepivance should not be given to you within 24 hours of your chemotherapy treatment.

Before you start receiving Kepivance, tell your health care professional if you are allergic to other products made from E. coli proteins.

Kepivance can cause possible tumor growth if it is used for nonblood related cancers. Talk to your doctor if you have any questions.

If you experience any of the following serious side effects from Kepivance, seek emergency medical attention or contact your doctor immediately:

  • fever;
  • breathing problems;
  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

Other common side effects include:

  • swelling;
  • pain;
  • joint pain;
  • increases in blood pancreas enzymes;
  • increased blood pressure; or
  • protein in the urine.

Kepivance has not yet been shown to be safe and effective in patients being treated for forms of cancer other than leukemia or lymphoma.

Kepivance is in the FDA pregnancy category C. This means that it is not known whether Kepivance will be harmful to an unborn baby. Do not use Kepivance without first talking to your doctor if you are pregnant or could become pregnant during treatment. Discuss with your doctor the appropriate use of birth control during treatment with Kepivance if necessary.

It is not known whether Kepivance passes into breast milk. Do not take Kepivance without first talking to your doctor if you are breast feeding a baby.

How should I use Kepivance?

Kepivance is administered as an intravenous (into the vein) infusion. Most often, Kepivance is administered in a hospital or clinic setting. If you are administering Kepivance at home, your healthcare provider will give you detailed instructions regarding preparation, administration, and storage of the medication.

Your doctor will determine the correct amount and frequency of treatment with Kepivance Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Kepivance vials should be stored in the refrigerator. Kepivance vials should be protected from light. Store Kepivance in the original carton until it is used. Do not freeze Kepivance products.

What happens if I miss a dose?

Contact your doctor if you miss a dose of Kepivance.

What happens if I overdose?

If an overdose of Kepivance is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a Kepivance overdose are not well known but may include headache.

What should I avoid?

Kepivance is given as an I .V. (in the vein) infusion for three days before you get chemotherapy and then three days after. Kepivance should not be given to you within 24 hours of your chemotherapy treatment.

What are the possible side effects of Kepivance?

If you experience any of the following serious side effects from Kepivance, seek emergency medical attention or contact your doctor immediately:

  • fever;
  • breathing problems;
  • skin and mucus membrane side effects such as rash, redness, swelling, itching, unusual sensations in the mouth, tongue color change, tongue thickening and changes in taste.

Other common side effects include:

  • swelling;
  • pain;
  • joint pain;
  • increases in blood pancreas enzymes;
  • increased blood pressure; or
  • protein in the urine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about Kepivance side effects. You may report side effects to FDA at 1-800-FDA-1088

See also: Side effects (in more detail)

What other drugs will affect Kepivance?

Kepivance can interact with heparin. If heparin is used to maintain your IV, your IV must be flushed with saline before and after Kepivance.

Other medications may interact with Kepivance. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with Kepivance.

Where can I get more information?

Your healthcare provider may have additional information about Kepivance that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 2.01. Revision date: 12/23/2008 9:24:35 AM

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