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In the US, Methotrexate (methotrexate systemic) is a member of the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants and is used to treat Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Acute Nonlymphocytic Leukemia, Bladder Cancer, Brain Tumor, Breast Cancer, Bullous Pemphigoid, Cervical Cancer, Choriocarcinoma, Cogan's Syndrome, Colorectal Cancer, Dermatomyositis, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Graft-versus-host disease, Head and Neck Cancer, Hodgkin's Lymphoma, Juvenile Idiopathic Arthritis, Lymphoma, Mantle Cell Lymphoma, Meningeal Leukemia, Mycosis Fungoides, Neoplastic Diseases, Non-Hodgkin's Lymphoma, Non-Small Cell Lung Cancer, Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Pemphigoid, Pemphigus, Pityriasis rubra pilaris, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Scleroderma, Small Cell Lung Cancer, Soft Tissue Sarcoma, Solid Tumors, Systemic Sclerosis, Trophoblastic Disease and Uveitis.

US matches:

UK matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories



Disease-modifying antirheumatic drug, DMARD

Antineoplastic agent: Dihydrofolate reductase inhibitor (folic acid antimetabolite)

Chemical Names

(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)metyl-metylamino]benzoyl]amino]pentanedioic acid (IUPAC)

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)metyl]metylamino]benzoyl]-

Foreign Names

Generic Names

  • Methotrexate (OS: BAN, JAN, USAN)
  • Méthotrexate (OS: DCF)
  • Metotrexato (OS: DCIT)
  • Methylaminopterin (IS)
  • MTX (IS)
  • Methotrexat (PH: Ph. Eur. 8)
  • Methotrexate (PH: BP 2015, JP XVI, Ph. Eur. 8, Ph. Int. 4, USP 37)
  • Méthotrexate (PH: Ph. Eur. 8)
  • Methotrexatum (PH: Ph. Eur. 8, Ph. Int. 4)
  • Methotrexate Sodium (OS: BANM)
  • Methotrexat disodium (IS)

Brand Names

International Drug Name Search


BANBritish Approved Name
BANMBritish Approved Name (Modified)
DCFDénomination Commune Française
DCITDenominazione Comune Italiana
IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.