Methotrexate

In the US, Methotrexate (methotrexate systemic) is a member of the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants and is used to treat Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Acute Nonlymphocytic Leukemia, Bladder Cancer, Brain Tumor, Breast Cancer, Bullous Pemphigoid, Cervical Cancer, Choriocarcinoma, Cogan's Syndrome, Colorectal Cancer, Dermatomyositis, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Graft-versus-host disease, Head and Neck Cancer, Hodgkin's Lymphoma, Juvenile Idiopathic Arthritis, Lymphoma, Mantle Cell Lymphoma, Meningeal Leukemia, Mycosis Fungoides, Neoplastic Diseases, Non-Hodgkin's Lymphoma, Non-Small Cell Lung Cancer, Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Pemphigoid, Pemphigus, Pityriasis rubra pilaris, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Scleroderma, Small Cell Lung Cancer, Soft Tissue Sarcoma, Solid Tumors, Systemic Sclerosis, Trophoblastic Disease and Uveitis.

US matches:

UK matches:

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

L01BA01,L04AX03

CAS registry number (Chemical Abstracts Service)

0000059-05-2

Chemical Formula

C20-H22-N8-O5

Molecular Weight

454

Therapeutic Categories

Immunosuppressant

Disease-modifying antirheumatic drug, DMARD

Antimetabolite

Antineoplastic agent: Dihydrofolate reductase inhibitor (folic acid antimetabolite)

Chemical Names

(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid (IUPAC)

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

Foreign Names

Generic Names

  • Methotrexate (OS: BAN, JAN, USAN)
  • Méthotrexate (OS: DCF)
  • Metotrexato (OS: DCIT)
  • Methylaminopterin (IS)
  • MTX (IS)
  • Methotrexat (PH: Ph. Eur. 7)
  • Methotrexate (PH: BP 2011, JP XV, Ph. Eur. 7, Ph. Int. 4, USP 34)
  • Méthotrexate (PH: Ph. Eur. 7)
  • Methotrexatum (PH: Ph. Eur. 7, Ph. Int. 4)
  • Methotrexate Sodium (OS: BANM)
  • Methotrexat disodium (IS)
  • Methotrexate for Injection (PH: USP 34)

Brand Names

International Drug Name Search

Glossary

TermDefinition
BANBritish Approved Name
BANMBritish Approved Name (Modified)
DCFDénomination Commune Française
DCITDenominazione Comune Italiana
IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

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