Drug Interaction Report
Drug interactions for the following 2 drug(s):
|Unsaved Drug List|
|Xyrem (sodium oxybate)|
Interactions between your selected drugs
Using sodium oxybate together with other medications that can affect the central nervous system such as clonazePAM may increase side effects like drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, and slow or shallow breathing. Occasionally, severe reactions may result in coma and even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drive, operate machinery, or perform other hazardous activities for at least six hours after taking sodium oxybate and until you know how these medications affect you. You should also avoid the use of alcohol during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Other drugs that your selected drugs interact with
- Klonopin (clonazepam) interacts with more than 400 other drugs.
- Xyrem (sodium oxybate) interacts with more than 200 other drugs.
Interactions between your selected drugs and food
Food may interfere with the absorption of sodium oxybate. You should wait at least 2 hours after eating before you take the first dose. Avoid alcohol during treatment, as it may add to the central nervous system effects of sodium oxybate and increase the risk of serious side effects such as respiratory depression, low blood pressure, fainting, coma, and even death. Do not drive, operate machinery, or perform other hazardous activities for at least six hours after taking sodium oxybate and until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic Duplication Warnings
Note: The benefits of taking this combination of medicines may outweigh any therapeutic duplication issues. Check with your healthcare provider to determine if adjustments to your medications are needed.
The maximum recommended number of ingredients in the 'CNS drugs' category to be taken concurrently is three. Your list includes four ingredients belonging to the 'CNS drugs' category:
- clonazepam (active ingredient in Klonopin)
- sodium oxybate (active ingredient in Xyrem)
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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