Drug Interaction Report
6 potential interactions and/or warnings found for the following 2 drugs:
- lomitapide
- Tri-Sprintec (ethinyl estradiol / norgestimate)
Interactions between your drugs
ethinyl estradiol lomitapide
Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate), lomitapide
Talk to your doctor before using lomitapide together with ethinyl estradiol. Combining these medications may significantly increase the blood levels and effects of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. At the same time, the absorption of ethinyl estradiol may be affected if you develop diarrhea or vomiting, which may reduce its effectiveness in preventing pregnancy. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid or limit the use of alcohol during treatment with lomitapide, and seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
norgestimate lomitapide
Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate), lomitapide
Talk to your doctor before using lomitapide together with norgestimate. Combining these medications may significantly increase the blood levels and effects of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. At the same time, the absorption of norgestimate may be affected if you develop diarrhea or vomiting, which may reduce its effectiveness in preventing pregnancy. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid or limit the use of alcohol during treatment with lomitapide, and seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
lomitapide food
Applies to: lomitapide
Taking lomitapide with food may increase gastrointestinal side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, constipation, indigestion, and gas. The absorption of any other oral medication you may take can be affected if you develop diarrhea or vomiting. To reduce the risk of gastrointestinal intolerance, lomitapide should be taken once daily with a glass of water, without food, at least 2 hours after the evening meal. You should also follow a low-fat diet (<20% of total calories from fat) during treatment with lomitapide, and avoid the consumption of grapefruit or grapefruit juice. Since lomitapide may cause injury to the liver, you should have no more than one alcoholic drink per day. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
norgestimate food
Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)
Grapefruit juice may increase the blood levels of certain medications such as norgestimate. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norgestimate. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.
ethinyl estradiol food
Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)
Information for this minor interaction is available on the professional version.
ethinyl estradiol food
Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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