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Drug Interaction Report

11 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

aspirin salicylamide

Applies to: aspirin / caffeine / salicylamide, aspirin / caffeine / salicylamide, Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Talk to your doctor before using aspirin together with salicylamide. Combining these medications may increase your risk of developing gastrointestinal ulcers and bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor immediately if you develop severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

aspirin caffeine

Applies to: aspirin / caffeine / salicylamide, aspirin / caffeine / salicylamide, Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Major

acetaminophen food

Applies to: Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenyltoloxamine food

Applies to: Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Alcohol can increase the nervous system side effects of phenyltoloxamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with phenyltoloxamine. Do not use more than the recommended dose of phenyltoloxamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

aspirin food

Applies to: aspirin / caffeine / salicylamide

Ask your doctor before using aspirin together with ethanol. Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

salicylamide food

Applies to: aspirin / caffeine / salicylamide, Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Ask your doctor before using salicylamide together with ethanol. Do not drink alcohol while taking salicylamide. Alcohol can increase your risk of stomach bleeding caused by salicylamide. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

caffeine food

Applies to: aspirin / caffeine / salicylamide, Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Information for this minor interaction is available on the professional version.

Minor

aspirin food

Applies to: aspirin / caffeine / salicylamide

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Stimulants

Therapeutic duplication

The recommended maximum number of medicines in the 'stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'stimulants' category:

  • aspirin / caffeine / salicylamide
  • Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Duplication

Cerebral stimulants

Therapeutic duplication

The recommended maximum number of medicines in the 'cerebral stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'cerebral stimulants' category:

  • aspirin / caffeine / salicylamide
  • Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Duplication

Nonsteroidal anti-inflammatories

Therapeutic duplication

The recommended maximum number of medicines in the 'nonsteroidal anti-inflammatories' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'nonsteroidal anti-inflammatories' category:

  • aspirin / caffeine / salicylamide
  • Cafgesic (acetaminophen / caffeine / phenyltoloxamine / salicylamide)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.