Skip to main content

Drug Interaction Report

11 potential interactions and/or warnings found for the following 2 drugs:

Filter by interaction and/or warning

Interactions between your drugs

Moderate

acetaminophen butalbital

Applies to: Margesic (acetaminophen / butalbital / caffeine), Margesic (acetaminophen / butalbital / caffeine)

Using acetaminophen together with butalbital may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

norethindrone butalbital

Applies to: Norethin 1/50 M (mestranol / norethindrone), Margesic (acetaminophen / butalbital / caffeine)

Butalbital may decrease the effectiveness of norethindrone. If you are using low-dose contraceptives, there is an increased risk of breakthrough bleeding and unintended pregnancy during combined therapy with butalbital. Alternative or additional methods of birth control should be used while taking butalbital. If you take hormone replacement for menopause, notify your doctor if you have decreased efficacy of your hormones. You may notice symptoms of increased hot flashes, vaginal dryness or menstrual abnormalities. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Switch to professional interaction data

Moderate

mestranol butalbital

Applies to: Norethin 1/50 M (mestranol / norethindrone), Margesic (acetaminophen / butalbital / caffeine)

Butalbital may decrease the effectiveness of mestranol. If you are using low-dose contraceptives, there is an increased risk of breakthrough bleeding and unintended pregnancy during combined therapy with butalbital. Alternative or additional methods of birth control should be used while taking butalbital. If you take hormone replacement for menopause, notify your doctor if you have decreased efficacy of your hormones. You may notice symptoms of increased hot flashes, vaginal dryness or menstrual abnormalities. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Switch to professional interaction data

Minor

acetaminophen mestranol

Applies to: Margesic (acetaminophen / butalbital / caffeine), Norethin 1/50 M (mestranol / norethindrone)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Major

acetaminophen food

Applies to: Margesic (acetaminophen / butalbital / caffeine)

Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Major

butalbital food

Applies to: Margesic (acetaminophen / butalbital / caffeine)

Ask your doctor before using butalbital together with ethanol, this can add to dizziness, drowsiness and other side effects of butalbital. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with butalbital. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

norethindrone food

Applies to: Norethin 1/50 M (mestranol / norethindrone)

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Switch to professional interaction data

Minor

caffeine food

Applies to: Margesic (acetaminophen / butalbital / caffeine)

Information for this minor interaction is available on the professional version.

Minor

mestranol food

Applies to: Norethin 1/50 M (mestranol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

norethindrone food

Applies to: Norethin 1/50 M (mestranol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

mestranol food

Applies to: Norethin 1/50 M (mestranol / norethindrone)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Learn more

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.