Calcium Phosphate Dihydrate Dibasic
Excipient (pharmacologically inactive substance)
What is Calcium Phosphate Dihydrate Dibasic?
Various calcium phosphates are used as diluents in the pharmaceutical industry. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable.[1]
Some calcium phosphate salts can be anhydrous, meaning the water has been removed from the salt form. Other calcium phosphates are termed dibasic, meaning they have two replaceable hydrogen atoms.
Calcium phosphate dihydrate dibasic is on the FDA Generally Regarded as Safe List (GRAS). There is no evidence in the available information on calcium phopshate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 03/24/2012
[2] FDA’s SCOGS database; calcium phosphate dibasic; SCOGS-Report Number: 32; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=58. Accessed March 24, 2012
Top Medications Containing Calcium Phosphate Dihydrate Dibasic
- Clonidine Hydrochloride 0.1 mg (Unichem Pharmaceuticals)
- Lisinopril 10 mg (Mylan Pharmaceuticals Inc.)
- Lisinopril 20 mg (Mylan Pharmaceuticals Inc.)
- Lisinopril 20 mg (Teva Pharmaceuticals USA)
- Paroxetine Hydrochloride 20 mg (Aurobindo Pharma)
- Paroxetine Hydrochloride 20 mg (Mylan Pharmaceuticals Inc.)
- Seroquel 100 mg (AstraZeneca Pharmaceuticals)
- Seroquel 200 mg (AstraZeneca Pharmaceuticals)
- Seroquel 25 mg (AstraZeneca Pharmaceuticals)
- Seroquel 300 mg (AstraZeneca Pharmaceuticals)
- Sertraline Hydrochloride 50 mg (Greenstone Limited)
- Sertraline Hydrochloride 100 mg (Greenstone Limited)
- Sertraline Hydrochloride 50 mg (Camber Pharmaceuticals)
- Sertraline Hydrochloride 100 mg (InvaGen Pharmaceuticals, Inc.)
- Sertraline Hydrochloride 50 mg (Aurobindo Pharma)
- Sertraline Hydrochloride 100 mg (Mylan Pharmaceuticals Inc.)
- Sertraline Hydrochloride 100 mg (Aurobindo Pharma)
- Sertraline Hydrochloride 50 mg (Mylan Pharmaceuticals Inc.)
- Zoloft 50 mg (Roerig)
- Zoloft 100 mg (Roerig)
