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Brondelate and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with Brondelate (guaifenesin / oxtriphylline).

Moderate

Oxtriphylline High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

methylxanthines - tachyarrhythmias

The use of theophyllines is associated with an increase in heart rate which may progress to supraventricular tachycardia or ventricular arrhythmia at high serum drug concentrations. Appearance of cardiac adverse effects is generally an indication of theophylline toxicity, although patients with a history of tachyarrhythmias may be more susceptible to the chronotropic effect of these drugs. Therapy with theophyllines should be administered cautiously in such patients. Caution is also advised in patients with hypertension, hyperthyroidism, angina pectoris, or recent myocardial infarction, since high dosages of the drugs are associated with positive inotropic as well as chronotropic effects. Clinical monitoring of serum drug concentrations is recommended to prevent toxicity.

References

  1. Hendeles L, Weinberger M, Johnson G (1978) "Monitoring serum theophylline levels." Clin Pharmacokinet, 3, p. 294-312
  2. Sessler CN (1990) "Theophylline toxicity: clinical features of 116 consecutive cases." Am J Med, 88, p. 567-76
  3. Schiff GD, Hegde HK, LaCloche L, Hryhorczuk DO (1991) "Inpatient theophylline toxicity: preventable factors." Ann Intern Med, 114, p. 748-53
  4. Marchlinski FE, Miller JM (1985) "Atrial arrhythmias exacerbated by theophylline: response to verapamil and evidence for triggered activity in man." Chest, 88, p. 931-4
  5. Levine JH, Michael JR, Guarnieri T (1985) "Multifocal atrial tachycardia: a toxic effect of theophylline." Lancet, 1, p. 12-4
  6. Taniguchi A, Ohe T, Shimorura K (1989) "Theophylline-induced ventricular tachycardia in a patient with chronic lung disease: sensitivity to verapamil." Chest, 96, p. 958-9
  7. Bittar G, Friedman HS (1991) "The arrhythmogenicity of theophylline: a multivariate analysis of clinical determinants." Chest, 99, p. 1415-20
  8. Patel AK, Skatrud JB, Thomsen JH (1981) "Cardiac arrhythmias due to oral aminophylline in patients with chronic obstructive pulmonary disease." Chest, 80, p. 661-5
  9. Albert S (1987) "Aminophylline toxicity." Pediatr Clin North Am, 34, p. 61-73
  10. Milgrom H, Bender B (1993) "Current issues in the use of theophylline." Am Rev Respir Dis, 147, s33-9
  11. Chazan R, Karwat K, Tyminska K, Tadeusiak W, Droszcz W (1995) "Cardiac arrhythmias as a result of intravenous infusions of theophylline in patients with airway obstruction." Int J Clin Pharmacol Ther, 33, p. 170-5
  12. Mccarthy M (1997) "Theophylline, beta-agonists, and cardiovascular death." Lancet, 349, p. 33
View all 12 references

Brondelate drug interactions

There are 222 drug interactions with Brondelate (guaifenesin / oxtriphylline).

Brondelate disease interactions

There are 7 disease interactions with Brondelate (guaifenesin / oxtriphylline) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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