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Drug Interactions between valbenazine and Victrelis

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

boceprevir valbenazine

Applies to: Victrelis (boceprevir) and valbenazine

Boceprevir may increase the blood levels and effects of valbenazine, such as sleepiness and an irregular heart rhythm problem called QT prolongation. Irregular heart rhythm problems may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. You may need a dose adjustment of valbenazine before using these medications together. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

valbenazine food

Applies to: valbenazine

Grapefruit and grapefruit juice may increase the blood levels and effects of valbenazine, such as drowsiness and an irregular heart rhythm problem called QT prolongation. Irregular heart rhythm problems may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have questions or concerns. Do not add grapefruit products to your diet, or increase or decrease the amount currently in your diet without first talking to your doctor. You may need a dose adjustment of valbenazine or more frequent monitoring by your doctor to safely use both valbenazine and grapefruit products. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

boceprevir food

Applies to: Victrelis (boceprevir)

Food significantly increases the absorption of boceprevir. You should take each dose of boceprevir with a meal or light snack. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.