Drug interactions between Tegretol XR and Topamax
| Results for the following 2 drugs: |
|---|
| Tegretol XR (carbamazepine) |
| Topamax (topiramate) |
Interactions between your selected drugs
carbamazepine ↔ topiramate
Applies to:Tegretol XR (carbamazepine) and Topamax (topiramate)
ADJUST DOSE: Carbamazepine, when coadministered with topiramate may lead to a 40% decrease in the plasma concentration of topiramate. The mechanism of action appears to be due to increased metabolism of topiramate.
MANAGEMENT: If dosages of topiramate have been adjusted up, reduction or withdrawal of carbamazepine during adjunctive therapy may require a downward dose adjustment of topiramate. No adjustment in carbamazepine dosage is required when topiramate adjunctive therapy is started. Patients should be monitored for seizure control and should be advised to notify their physician if seizure control worsens.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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