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Drug Interactions between taurine and Verelan PM

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

verapamil taurine

Applies to: Verelan PM (verapamil) and taurine

Consumer information for this interaction is not currently available.

MONITOR: Theoretically, concomitant use of taurine and antihypertensive agents or vasodilators may have additive blood pressure-lowering effects. The proposed mechanism has not been established but has been suggested, primarily through studies in animal models, that taurine has a homeostatic function on vascular smooth muscle and cardiac muscle. Several mechanisms by which taurine has been proposed to promote vasodilation include effects on the nitric oxide system, endothelial function, and inhibition of the renin-angiotensin-aldosterone and sympathetic systems. A 2018 meta-analysis reviewing the effects of orally administered taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans showed that, in the 7 studies that met the inclusion criteria, treatment with oral taurine led to a statistically significant improvement in SBP and DBP compared with placebo. The mean reduction in blood pressure was approximately 3 mmHg for both systolic and diastolic readings, with a range of 0 to 15 mmHg and 0 to 7 mmHg for SBP and DBP, respectively. The effects of taurine supplementation may also be more significant in those who are pre-hypertensive or hypertensive compared to those with normal or moderately low blood pressure, regardless of their health status. However, clinical data are limited.

MANAGEMENT: Caution and monitoring for hypotension are recommended if oral taurine supplements are used in combination with antihypertensives. Patients should be advised to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

References

  1. waldron m, patterson sd, Tallent J, Jeffries O "The effects of oral taurine on resting blood pressure in humans: a meta analysis" Curr Hypertens Rep 20 (2018): 1-8

Drug and food interactions

Moderate

verapamil food

Applies to: Verelan PM (verapamil)

You may take verapamil with or without food, but take it the same way every time. You should avoid consuming grapefruit or grapefruit juice as much as possible during treatment with verapamil. If you have been regularly consuming grapefruit or grapefruit juice with verapamil, do not increase or decrease the amounts of these products in your diet without first talking to your doctor. Grapefruit juice can increase the blood levels and effects of verapamil. Contact your doctor if you experience sudden, unexplained weight gain; swelling of the hands, ankles, or feet; chest pain; or difficulty breathing. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

verapamil food

Applies to: Verelan PM (verapamil)

Ask your doctor before using verapamil together with ethanol. Verapamil may increase the blood levels and intoxicating effects of ethanol. This can cause symptoms of extreme drowsiness, confusion, and nausea. If you experience any of these side effect you should avoid activities requiring mental alertness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

verapamil food

Applies to: Verelan PM (verapamil)

Using verapamil together with multivitamin with minerals can decrease the effects of verapamil. Talk with your doctor before using verapamil and multivitamin with minerals together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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