Drug interactions between Synthroid and Uniphyl
| Results for the following 2 drugs: |
|---|
| Synthroid (levothyroxine) |
| Uniphyl (theophylline) |
Interactions between your selected drugs
theophylline ↔ levothyroxine
Applies to:Uniphyl (theophylline) and Synthroid (levothyroxine)
MONITOR: The metabolism of theophylline is directly related to thyroid function. Theophylline clearance is decreased in hypothyroid patients and increased in hyperthyroid patients. Toxicity or subtherapeutic levels may occur. Similar interactions may occur with other methylxanthines.
MANAGEMENT: When thyroid hormone dosage is instituted, discontinued, or changed, close observation for altered theophylline effect and serum concentrations is recommended. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms, or any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeats.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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