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Drug Interactions between sirolimus and voxelotor

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sirolimus voxelotor

Applies to: sirolimus and voxelotor

Voxelotor may increase the blood levels of sirolimus. In some cases, this can increase the risk of serious side effects such as kidney problems, diabetes, nervous system disorders, hyperkalemia (high potassium levels in the blood), high blood pressure, irregular heart rhythm, heart failure, infections, and various types of malignancies including lymphoma and skin cancer. You may need a dose adjustment if you have been taking sirolimus and are starting treatment with voxelotor. Contact your doctor if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Also seek medical attention if you experience frequent urination, increased hunger or thirst, loss of appetite, confusion, tremor, numbness or tingling, seizures, vision changes, sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, and chest pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

sirolimus food

Applies to: sirolimus

Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.

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Moderate

voxelotor food

Applies to: voxelotor

Grapefruit juice may increase the blood levels of certain medications such as voxelotor. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with voxelotor. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.