Drug Interactions between Rezurock and voriconazole
This report displays the potential drug interactions for the following 2 drugs:
- Rezurock (belumosudil)
- voriconazole
Interactions between your drugs
No interactions were found between Rezurock and voriconazole. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Rezurock
A total of 130 drugs are known to interact with Rezurock.
- Rezurock is in the drug class selective immunosuppressants.
- Rezurock is used to treat Graft-versus-host disease.
voriconazole
A total of 658 drugs are known to interact with voriconazole.
- Voriconazole is in the drug class azole antifungals.
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Voriconazole is used to treat the following conditions:
- Aspergillosis, Invasive
- Blastomycosis
- Candidemia
- Coccidioidomycosis, Meningitis
- Cutaneous Fungal Infection
- Esophageal Candidiasis
- Eumycetoma
- Fungal Infection, Internal and Disseminated
- Fungal Meningitis
- Fungal Pneumonia
- Fusariosis
- Ocular Fungal Infection
- Pseudoallescheriosis
- Systemic Fungal Infection
Drug and food interactions
voriconazole food
Applies to: voriconazole
You may experience reduced absorption of voriconazole in the presence of food. Take voriconazole on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.
belumosudil food
Applies to: Rezurock (belumosudil)
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Administration with food increases the oral bioavailability of belumosudil. The mechanism has not been described. Administration of belumosudil (200 mg single oral dose) in healthy subjects, with a fatty and calorie-rich meal (approximately half of the calories were contained in the fat) increased the mean belumosudil peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 120% and 100%, respectively, compared to administration under fasting conditions. The time to reach peak concentration (Tmax) was delayed by 30 minutes. Administration of oral belumosudil 200 mg once daily with food in patients with chronic graft-versus-host disease (chronic GVHD) lead to steady-state concentrations of the drug with an accumulation ration of 1.4.
MANAGEMENT: To ensure maximal oral absorption, belumosudil should be administered with a meal, every day at the same time.
References
- (2024) "Product Information. Rezurock (belumosudil)." Sanofi
- (2024) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals, 11/2023
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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