Drug interactions between propylthiouracil and Synthroid
| Results for the following 2 drugs: |
|---|
| propylthiouracil |
| Synthroid (levothyroxine) |
Interactions between your selected drugs
levothyroxine ↔ propylthiouracil
Applies to:Synthroid (levothyroxine) and propylthiouracil
GENERALLY AVOID: Antithyroid agents such as methimazole and propylthiouracil can affect the therapeutic response to thyroid hormone therapy. These agents decrease thyroid hormone secretion, which may result in hypothyroidism. Conversely, thyroid hormone therapy can antagonize the pharmacologic effects of antithyroid agents by supplying an exogenous source of the hormone.
MANAGEMENT: Concomitant use of antithyroid agents and thyroid hormones should generally be avoided due to mutually negating effects.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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