Drug interactions between Prograf and sodium bicarbonate
Results for the following 2 drugs: |
|
|---|---|
| Prograf (tacrolimus) | |
| sodium bicarbonate | |
Interactions between your selected drugs
sodium bicarbonate ⇔ tacrolimus
Applies to: sodium bicarbonate and Prograf (tacrolimus)
ADJUST DOSING INTERVAL: Sodium bicarbonate has been reported to cause widely variable trough plasma levels and reduced blood concentrations of tacrolimus when given close to the time of administration of tacrolimus. No other details were available in the report. Based on in vitro data, the mechanism appears to involve a pH-mediated degradation of tacrolimus. A 75% loss of tacrolimus was observed within 24 hours when tacrolimus was incubated in simulated gastric fluid with sodium bicarbonate. Other antacids tested (aluminum-magnesium hydroxide, magnesium oxide, calcium carbonate) also led to loss of tacrolimus.
MANAGEMENT: Until more data are available, it may be prudent to separate the times of administration of tacrolimus and sodium bicarbonate by at least two hours.
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