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Drug Interactions between probenecid and sodium phenylacetate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid sodium phenylacetate

Applies to: probenecid and sodium phenylacetate

Ask your doctor before using probenecid together with sodium phenylacetate. Probenecid may decrease the effects of sodium phenylacetate for the treatment of acute hyperammonemia in patients with urea cycle disorders. Hyperammonemia is the presence of ammonia or some of its compounds in the blood, thought to be formed from the breakdown of urea. It usually results in low temperature, weak pulse, gastroenteric symptoms, and coma. It may be appropriate to avoid using probenecid during treatment of hyperammonemia due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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