Drug interactions between Prezista and tenofovir
| Results for the following 2 drugs: |
|---|
| Prezista (darunavir) |
| tenofovir |
Interactions between your selected drugs
tenofovir ↔ darunavir
Applies to:tenofovir and Prezista (darunavir)
Coadministration of tenofovir disoproxil fumarate and darunavir/ritonavir may result in increased plasma concentrations of both tenofovir and darunavir. The proposed mechanism is competitive inhibition of CYP450 3A4 metabolism. In 12 study subjects, administration of darunavir/ritonavir (300 mg/100 mg twice a day) with tenofovir disoproxil fumarate (300 mg once a day) increased the peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of darunavir by 16%, 21% and 24%, respectively, compared to administration without tenofovir disoproxil fumarate. Tenofovir Cmax, AUC, and Cmin also increased by 24%, 22%, and 37%, respectively, in the presence of darunavir/ritonavir. No dosage adjustments should be necessary during coadministration of darunavir/ritonavir and tenofovir disoproxil fumarate.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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